Urologic manifestations of IgG4-related disease

Benjamin Enrique Montaño Roca; Davide Vanacore; Gustavo Gallegos Sánchez; César Eduardo Rosales Velázquez; Guillermo Enrique Ruvalcaba Oceguera; Marco Antonio Aragón Castro; Rubén Gutiérrez Rosales; Romain Boissier

doi:10.48193/revistamexicanadeurologa.v80i5.610

Authors

Benjamin Enrique Montaño Roca Instituto de Seguridad Social del Estado de México y Municipios. Centro Médico Arturo Montiel Rojas, Toluca, México. https://orcid.org/0000-0001-8750-0320
Davide Vanacore Aix-Marseille Université, Marsella, Francia https://orcid.org/0000-0001-5229-7385
Gustavo Gallegos Sánchez Instituto de Seguridad Social del Estado de México y Municipios. Centro Médico Arturo Montiel Rojas, Toluca, México. https://orcid.org/0000-0003-4671-241X
César Eduardo Rosales Velázquez Instituto de Seguridad Social del Estado de México y Municipios. Centro Médico Arturo Montiel Rojas, Toluca, México. https://orcid.org/0000-0003-1853-1064
Guillermo Enrique Ruvalcaba Oceguera Instituto de Seguridad Social del Estado de México y Municipios. Centro Médico Arturo Montiel Rojas, Toluca, México. https://orcid.org/0000-0003-4673-976X
Marco Antonio Aragón Castro Instituto de Seguridad Social del Estado de México y Municipios. Centro Médico Arturo Montiel Rojas, Toluca, México. https://orcid.org/0000-0002-6433-6094
Rubén Gutiérrez Rosales Instituto de Seguridad Social del Estado de México y Municipios. Centro Médico Arturo Montiel Rojas, Toluca, México. https://orcid.org/0000-0003-2522-6287
Romain Boissier Aix-Marseille Université, Marsella, Francia https://orcid.org/0000-0001-6428-0273

DOI:

https://doi.org/10.48193/revistamexicanadeurologa.v80i5.610

Keywords:

Pseudotumor, IgG4, Urology, Autoinmune

Abstract

IgG4-related disease (IgG4-RD) is a clinical entity characterized by elevated serum IgG4 and tumor-like inflammation, with tissue infiltration by IgG4 and plasma cells. IgG4-RD is rare, but clinically significant, and its urologic manifestations have been reported in the literature. The present review covers a broad spectrum, describing the pathologies related to the area of urology.

In 2003, Terumi Kamisawa was the first to recognize IgG4-RD, characterized by multiorgan lesions in patients with autoimmune pancreatitis and classified as an inflammatory and fibrotic entity with a dense lymphoplasmacytic infiltrate, positive for IgG4.^(1–3) It presents in middle-aged patients, between 59-68 years of age, with no clear distribution by sex, ^(4–6) and has different clinical presentations. The main urologic manifestations are inflammatory pseudotumors and lower urinary tract symptoms. The present article offers a clear, general overview of the disease, encompassing its pathophysiology, diagnosis, and treatment, from the perspective of urology.

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Urologic manifestations of IgG4-related disease

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