Neuromodulation through electrical stimulation of the tibial nerve for the treatment of enuresis: current status
DOI:
https://doi.org/10.48193/revistamexicanadeurologa.v79i3.454Keywords:
Enuresis, Tibial nerve, Neuromodulation, Electrical nerve stimulation, ChildrenAbstract
Objective. Enuresis is urinary incontinence in children and it negatively affects their quality of life, causing psychologic and social stress. There is no consensus on the treatment of enuresis using neuromodulation through percutaneous, electrical posterior tibial nerve stimulation (ptns). The present review analyzes the current status of enuresis treatment with neuromodulation through ptns.
Materials and Methods. A systematic search in the PubMed, Cochrane, and Scopus databases was carried out for articles on enuresis published within the last ten years, in Spanish and English.
Results. Only 5 articles referred to ptns and enuresis, 3 in English and 2 in Spanish. The overall clinical response rate was from 9% to 85%, with almost no adverse effects. Treatment was reported as ineffective in 20% of patients in one of the studies.
Conclusions. Neuromodulation through ptns offers good results as treatment for enuresis, but controlled studies are needed to determine its therapeutic relevance, especially regarding the monosymptomatic condition.
References
Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, et al. The standardisation of terminology in lower urinary tract function: Report from the standardisation sub-committee of the International Continence Society. Neurourol urodynamics. 2002;21:167-178. doi: https://doi.org/10.1016/S0090-4295(02)02243-4
Coyne KS, Wein A, Nicholson S, Kvasz M, Chen C, Milsom I. Economic Burden of Urgency Urinary Incontinence. J Manag Care Pharm. 2014;20(2):130-140. doi: https://doi.org/10.18553/jmcp.2014.20.2.130
Coyne KS, Matza LS, Kopp Z, Abrams P. The Validation of the Patient Perception of Bladder Condition (PPBC): A Single-Item Global Measure for Patients with Overactive Bladder. Eur Urol. 2006;49(6):1079-1086. doi: https://doi.org/10.1016/j.eururo.2006.01.007
van Engelenburg–van Lonkhuyzen ML, Bols EMJ, Benninga MA, Verwijs WA, de Bie RA. Bladder and bowel dysfunctions in 1748 children referred to pelvic physiotherapy: clinical characteristics and locomotor problems in primary, secondary, and tertiary healthcare settings. Eur J Pediatr. 2017;176(2):207–16. doi: https://dx.doi.org/10.1007%2Fs00431-016-2824-5.
Maternik M, Krzeminska K, Zurowska A. The management of childhood urinary incontinence. Pediatr Nephrol. 2015;30(1):41–50. doi: https://doi.org/10.1007/s00467-014-2791-x
Nevéus T, von Gontard A, Hoebeke P, Hjälmås K, Bauer S, Bower W, et al. The standardization of terminology of lower urinary tract function in children and adolescents: report from the Standardisation Committee of the International Children’s Continence Society. J Urol. 2006;176(1):314–24. doi: https://doi.org/10.1016/S0022-5347(06)00305-3
Austin PF, Bauer SB, Bower W, Chase J, Franco I, Hoebeke P, et al. The standardization of terminology of lower urinary tract function in children and adolescents: Update report from the standardization committee of the International Children’s Continence Society. Neurourol Urodyn. 2016;35(4):471–81. doi: https://doi.org/10.1002/nau.22751
Anduaga JJC y. Cuestionario breve de tamizaje y diagnóstico de problemas de salud mental en niños y adolescentes: algoritmos para síndromes y su prevalencia en la Ciudad de México. Segunda parte. Salud Mental. 2007;30(1):48–55. [accessed 11 Jul 2019] Available from: http://www.revistasaludmental.mx/index.php/salud_mental/article/view/1148.
Feria M, Cárdenas M, Vázquez J, Palacios L, de la Peña F. Guía clínica para el manejo de los trastornos de eliminación (enuresis y encopresis ). In: Berenson S, Del Bosque J, Alfaro J, Medina-Mora M, eds. Guías Clínicas Para La Atención de Transtornos Mentales. México: Instituto Nacional de Psiquiatría; 2010:5-21.
Milsom I, Altman D, Artwright R, et al. Committee 1. Epidemiology of Urinary Incontinence (UI) and other Lower Urinary Tract Symptoms (LUTS) , Pelvic Organ Prolapse (POP) and Annal Incontinence (AI). In: Abrams P, Cardozo L, Wagg A, Wein A, eds. International Consultation on Incontinence, Tokyo, September 2016. 6a ed. London, UK; 2017:1-92.
Bakhtiar K, Pournia Y, Ebrahimzadeh F, Farhadi A, Shafizadeh F, Hosseinabadi R. Prevalence of nocturnal enuresis and its associated factors in primary school and preschool children of khorramabad in 2013. Int J Pediatr. 2014;2014:120686. doi: https://doi.org/10.1155/2014/120686
Nevéus T. Nocturnal enuresis-theoretic background and practical guidelines. Pediatr Nephrol. 2011;26(8):1207–14. doi: https://doi.org/10.1007/s00467-011-1762-8
Raheem AA, Farahat Y, El-Gamal O, Ragab M, Radwan M, El-Bahnasy AH, et al. Role of posterior tibial nerve stimulation in the treatment of refractory monosymptomatic nocturnal enuresis: a pilot study. J Urol. 2013;189(4):1514–8. doi: https://doi.org/10.1016/j.juro.2012.10.059
Schlomer B, Rodriguez E, Weiss D, Copp H. Parental beliefs about nocturnal enuresis causes, treatments, and the need to seek professional medical care. J Pediatr Urol. 2013;9(6 0 0):1043–8. [accessed 11 Jul 2019] Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648250/. doi: https://dx.doi.org/10.1016%2Fj.jpurol.2013.02.013
de Jesus LE, Tomé A, Cobe D, Camelier P. Psychosocial and respiratory disease related to severe bladder dysfunction and non-monosymptomatic enuresis. J Pediatr Urol. 2016;12(2):126.e1-6. doi: https://doi.org/10.1016/j.jpurol.2015.11.012.
Pérez-Martínez C, Palacios-Galicia J, Vargas-Díaz I, Cruz-Gómez Y. Efecto de la electroestimulación percutánea del nervio tibial en pacientes con enuresis monosintomática . Experiencia inicial en México. Rev Mex Urol. 2018;78(1):21-29.
Neveus T, Eggert P, Evans J, Macedo A, Rittig S, Tekgül S, et al. Evaluation of and treatment for monosymptomatic enuresis: a standardization document from the International Children’s Continence Society. J Urol. 2010;183(2):441–7. doi: https://doi.org/10.1016/j.juro.2009.10.043
Roth TJ, Vandersteen DR, Hollatz P, Inman BA, Reinberg YE. Sacral neuromodulation for the dysfunctional elimination syndrome: a single center experience with 20 children. J Urol. 2008;180(1):306–11; discussion 311. doi: https://doi.org/10.1016/j.juro.2008.03.033
Barroso U, Viterbo W, Bittencourt J, Farias T, Lordêlo P. Posterior tibial nerve stimulation vs parasacral transcutaneous neuromodulation for overactive bladder in children. J Urol. 2013;190(2):673–7. doi: https://doi.org/10.1016/j.juro.2013.02.034
Patidar N, Mittal V, Kumar M, Sureka SK, Arora S, Ansari MS. Transcutaneous posterior tibial nerve stimulation in pediatric overactive bladder: A preliminary report. J Pediatr Urol. 2015;11(6):351.e1-6. doi: https://doi.org/10.1016/j.jpurol.2015.04.040
Lecompte J-F, Hery G, Guys J-M, Louis-Borrione C. Evaluation of transcutaneous electrical posterior tibial nerve stimulation for the treatment of fecal and urinary leaks in children: preliminary results. J Pediatr Surg. 2015;50(4):630–3. doi: https://doi.org/10.1016/j.jpedsurg.2014.05.033
Wibisono E, Rahardjo HE. Effectiveness of Short Term Percutaneous Tibial Nerve Stimulation for Non-neurogenic Overactive Bladder Syndrome in Adults: A Meta-analysis. Acta Med Indones. 2015;47(3):188–200.
Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. doi: https://doi.org/10.1371/journal.pmed.1000097
van Balken MR, Vergunst H, Bemelmans BLH. The use of electrical devices for the treatment of bladder dysfunction: a review of methods. J Urol. 2004;172(3):846–51. doi: https://doi.org/10.1097/01.ju.0000134418.21959.98
Capitanucci ML, Camanni D, Demelas F, Mosiello G, Zaccara A, De Gennaro M. Long-term efficacy of percutaneous tibial nerve stimulation for different types of lower urinary tract dysfunction in children. J Urol. 2009;182(4 Suppl):2056–61. doi: https://doi.org/10.1016/j.juro.2009.03.007
Fernández-Pineda I, Pérez Espejo MP, Fernández Hurtado MA, Barrero Candau R, García Merino F. [Biofeedback and electrostimulation in the treatment of non monosymptomatic enuresis]. Cir Pediatr. 2008;21(2):89–91.
de Groat WC, Griffiths D, Yoshimura N. Neural control of the lower urinary tract. Compr Physiol. 2015;5(1):327–96. doi: https://doi.org/10.1002/cphy.c130056
Rickenbacher E, Baez MA, Hale L, Leiser SC, Zderic SA, Valentino RJ. Impact of overactive bladder on the brain : Central sequelae of a visceral pathology. PNAS. 2008;105(30):10589–10594. doi: https://doi.org/10.1073/pnas.0800969105
Gad PN, Roy RR, Zhong H, Gerasimenko YP, Taccola G, Edgerton VR. Neuromodulation of the neural circuits controlling the lower urinary tract. Exp Neurol. 2016;285(Pt B):182–9. doi: https://doi.org/10.1016/j.expneurol.2016.06.034
Amend B, Matzel KE, Abrams P, de Groat WC, Sievert K-D. How does neuromodulation work. Neurourol Urodyn. 2011;30(5):762–5. doi: https://doi.org/10.1002/nau.21096.
McGee MJ, Grill WM. Modeling the spinal pudendo-vesical reflex for bladder control by pudendal afferent stimulation. J Comput Neurosci. 2016;40(3):283–96. doi: https://doi.org/10.1007/s10827-016-0597-5
De Groat WC, Ryall RW. Recurrent inhibition in sacral parasympathetic pathways to the bladder. J Physiol (Lond). 1968;196(3):579–91. doi: https://doi.org/10.1113/jphysiol.1968.sp008524
Matsuta Y, Mally AD, Zhang F, Shen B, Wang J, Roppolo JR, et al. Contribution of opioid and metabotropic glutamate receptor mechanisms to inhibition of bladder overactivity by tibial nerve stimulation. Am J Physiol Regul Integr Comp Physiol. 2013;305(2):R126-133. doi: https://doi.org/10.1152/ajpregu.00572.2012.
Finazzi-Agrò E, Rocchi C, Pachatz C, Petta F, Spera E, Mori F, et al. Percutaneous tibial nerve stimulation produces effects on brain activity: study on the modifications of the long latency somatosensory evoked potentials. Neurourol Urodyn. 2009;28(4):320–4. doi: https://doi.org/10.1002/nau.20651
Wright AJ, Haddad M. Electroneurostimulation for the management of bladder bowel dysfunction in childhood. Eur J Paediatr Neurol. 2017;21(1):67–74. doi: https://doi.org/10.1016/j.ejpn.2016.05.012
De Gennaro M, Capitanucci ML, Mosiello G, Zaccara A. Current state of nerve stimulation technique for lower urinary tract dysfunction in children. J Urol. 2011;185(5):1571–7. doi: https://doi.org/10.1016/j.juro.2010.12.067
