Penile cancer an unnoticed pathology: report of 6 cases

Authors

  • Gabriela Escobar-Pabón Hospital de Especialidades Eugenio Espejo, Quito, Ecuador.
  • Juan-Martín Calderón-Vivanco Hospital General Pablo Arturo Suarez, Quito, Ecuador.
  • Diego Orozco-Delgado Hospital Vozandes Quito, Quito, Ecuador.
  • Carol Vallejo-Suárez Hospital General Enrique Garcés, Quito, Ecuador.
  • Daniel Chininin-Moreno Hospital General Enrique Garcés, Quito, Ecuador.
  • Julio Vaca-Salazar Hospital General Enrique Garcés, Quito, Ecuador.
  • Dayanna Escobar-Estrada Hospital General Enrique Garcés, Quito, Ecuador.

DOI:

https://doi.org/10.48193/revistamexicanadeurologa.v83i1.953

Keywords:

Squamous Cell Carcinoma, Lymphadenectomy, TNM Classification, Penile Cancer

Abstract

Objective: To describe 6 cases of penile cancer and examine their surgical management in a tertiary level hospital.

Methods: Retrospective and descriptive study of penile cancer cases from april 2020 to may 2022 at the Hospital de Especialidades Eugenio Espejo in the city of Quito. Only cases with complete clinical history, confirmatory histopathological diagnosis and post-surgical controls were included.

Results: We describe 6 patients with penile cancer with an average age of 69 years. In the histopathological study, five patients were diagnosed with squamous cell carcinoma and one with nodular melanoma. The most frequent location was on the glans penis in four individuals. According to TNM classification, two patients were stratified as T3Nx, one as T3N1, one as T3N2, one as T4 and one as T4bN3b. In half of the cases, the treatment of choice was total penectomy plus bilateral inguinal lymphadenectomy.

Conclusions: Although penile cancer is a rare pathology, the identification of risk factors and primary lesions can help in the early diagnosis of cancer, thus avoiding metastasis to structures adnexal to the penis and consequent penectomies.

References

Douglawi A, Masterson TA. Penile cancer epidemiology and risk factors: A contemporary review. Curr Opin Urol. 2019 Mar 1;29(2):145–9. DOI: https://doi.org/10.1097/MOU.0000000000000581

Marchioni M, Berardinelli F, De Nunzio C, Spiess P, Porpiglia F, Schips L, et al. New insight in penile cancer. Minerva Urol e Nefrol. 2018;70(6):559–69. DOI: https://doi.org/10.23736/S0393-2249.18.03215-0

Thomas A, Necchi A, Muneer A, Tobias-Machado M, Tran ATH, Van Rompuy AS, et al. Penile cancer. Nat Rev Dis Prim. 2021;7(1). DOI: https://doi.org/10.1038/s41572-021-00246-5

Ahmed ME, Khalil MI, Kamel MH, Karnes RJ, Spiess PE. Progress on Management of Penile Cancer in 2020. Curr Treat Options Oncol. 2021;22(0). DOI: https://doi.org/10.1007/s11864-020-00802-3

Hakenberg OW, Dräger DL, Erbersdobler A, Naumann CM, Jünemann KP, Protzel C. The Diagnosis and Treatment of Penile Cancer. Dtsch Arztebl Int. 2018 Sep 28;115(39):646. DOI: https://doi.org/10.3238/arztebl.2018.0646

Cardona CEM, García-Perdomo HA. Incidence of penile cancer worldwide: systematic review and meta-analysis. Rev Panam Salud Pública. 2018 Apr 12;41:e117. DOI: https://doi.org/10.26633/RPSP.2017.117.

Bandini M, Ahmed M, Basile G, Watkin N, Master V, Zhu Y, et al. A global approach to improving penile cancer care. Nat Rev Urol. 2021 Dec 22;1–9. DOI: https://doi.org/10.1038/s41585-021-00557-y

Cabrera-Mora NA, Sánchez-Núñez JE, Hernández-Hernández RA, Rodríguez-Valle ED, De los Santos-González JA, Rosas-Nava JE, et al. Clinical and pathologic characteristics of penile cancer: Current experience at a tertiary care hospital center in Mexico. Rev Mex Urol. 2020;80(5):1–9. DOI: https://doi.org/10.48193/revistamexicanadeurologa.v80i5.679

Vuichoud C, Klap J, Loughlin KR. The Emerging Role and Promise of Biomarkers in Penile Cancer. Urol Clin North Am. 2016;43(1):135–43. DOI: https://doi.org/10.1016/j.ucl.2015.08.012

Hakenberg OW, Compérat EM, Minhas S, Necchi A, Protzel C, Watkin N. EAU guidelines on penile cancer: 2014 update. Eur Urol. 2015;67(1):142–50. DOI: https://doi.org/10.1016/j.eururo.2014.10.017

Sánchez-Bermeo AF, Martínez-Carrillo G, Torres-Aguilar J, Bernal-Hernández J. Penectomía parcial como tratamiento para el cáncer de pene localizado, Hospital Juárez de México. Rev Mex Urol. 2016;76(3):182–8. DOI: http://dx.doi.org/10.1016/j.uromx.2016.01.009

Ferrándiz-pulido C, de Torres I, García-patos V. Carcinoma escamoso de pene. Actas Dermosfilogáficas. 2012;103(6):478–87. DOI: https://doi.org/10.1016/j.ad.2011.08.008

May A, Joshi P, Davaro F, Raza SJ, Siddiqui S, Hamilton Z. Trends in treatment of cT1 penile cancer: Analysis of the National Cancer Database. Urol Oncol. 2020 Aug 1;38(8):688.e1-688.e9. DOI: https://doi.org/10.1016/j.urolonc.2020.04.013

Teh J, Duncan C, Qu L, Guerra G, Narasimhan V, Pham T, et al. Inguinal lymph node dissection for penile cancer: A contemporary review. Vol. 9, Translational Andrology and Urology. AME Publications; 2020. p. 3210–8. DOI: https://doi.org/10.21037/tau.2019.08.37

Niyogi D, Noronha J, Pal M, Bakshi G, Prakash G. Management of clinically node-negative groin in patients with penile cancer. Indian J Urol. 2020 Jan 1;36(1):8. DOI: https://doi.org/10.4103/iju.IJU_221_19

Published

2023-03-08

Issue

Section

Clinical cases