Atypical metastases from a renal tumor
DOI:
https://doi.org/10.48193/revistamexicanadeurologa.v79i1.389Keywords:
Kidney tumor, Metastasis, TreatmentAbstract
Background: The aim of the present work was to present three clinical cases with uncommon presentations of metastatic kidney cancer.
Clinical cases: The first case was that of a woman that presented with metastasis to the thyroid gland after thyroidectomy. The rest of the extension studies were negative, and she did not require adjuvant treatment. The second case was a woman that came to the emergency department due to urinary retention secondary to urethral metastasis from a kidney tumor, with no metastases at other levels. The third case was a man that presented with recurrence of papillary renal cell carcinoma in the bladder mucosa associated with lung metastases.
Discussion: Thirty-four percent of metastases to the thyroid gland have a renal origin. The urethra is an uncommon site for metastasis. In general, bladder metastases from renal carcinoma have a poor prognosis, with only 56 cases described in the literature. The treatment of choice for resectable lesions is surgical extirpation, and anti-angiogenic therapy is reserved for nonresectable lesions.
Conclusions: The thyroid gland, bladder, and urethra are uncommon sites of metastases from kidney cancer. They tend to indicate advanced disease stages and treatment is surgical extirpation in cases of resectable lesions.
References
Hock LM, Lynch J, Balaji KC. Increasing incidence of all stages of kidney cancer in the last 2 decades in the United States: an analysis of surveillance, epidemiology and end results program data. J Urol. 2002;167(1):57-60.
Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, Leibovich BC, et al. A multifactorial postoperative surveillance model for patients with surgically treated clear cell renal cell carcinoma. J Urol. 2003;170(6):2225-32.
Villumsen AL, Mevik K, Fjøsne HE, Brekke MB, Haugen OA. Late onset metastases to the thyroid gland from renal carcinoma. Tidsskr Den Nor Laegeforening Tidsskr Prakt Med Ny Raekke. 2013;133(21):2262-5.
Medas F, Calò PG, Lai ML, Tuveri M, Pisano G, Nicolosi A. Renal cell carcinoma metastasis to thyroid tumor: a case report and review of the literature. J Med Case Reports. 2013;7(1):265.
Chitale SV, Burgess NA, Sethia KK, Love K, Roberts PF. Management of urethral metastasis from colorectal carcinomas. ANZ J Surg. 2004;74(10):925-7.
Tefilli MV, Stefani SD, Mariano MB. Urethral metastasis of lung carcinoma with germinative cell features. Int Braz J Urol [Internet]. octubre de 2003 [citado 20 de marzo de 2019];29(5):431-3. Disponible en: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1677-55382003000500008&lng=en&nrm=iso&tlng=en
Senzaki H, Okamura T, Tatsura H, Watase H. Urethral metastasis from renal cell carcinoma. Int J Urol [Internet]. 2003 [citado 20 de marzo de 2019];10(12):661-3. Disponible en: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1442-2042.2003.00717.x
Gelister JS, Falzon M, Crawford R, Chapple CR, Hendry WF. Urinary tract metastasis from renal carcinoma. Br J Urol. marzo de 1992;69(3):250-2.
Matsumoto K, Hayakawa N, Nakamura S, Oya M. Bladder metastasis from renal cell carcinoma: retrospective analysis of 65 reported cases. Clin Exp Metastasis [Internet]. febrero de 2015 [citado 20 de marzo de 2019];32(2):135-41. Disponible en: http://europepmc.org/abstract/med/25630270
Raviv S, Eggener SE, Williams DH, Garnett JE, Pins MR, Smith ND. Long-term survival after «drop metastases» of renal cell carcinoma to the bladder. Urology. octubre de 2002;60(4):697.
