Sexual behavior and other risk factors for prostate cancer

Authors

  • Ulises Ángeles-Garay Hospital de Especialidades Centro Médico La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, México https://orcid.org/0000-0002-4338-7669
  • Juan Joel Sandoval-Sánchez Hospital de Especialidades Centro Médico La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, México https://orcid.org/0000-0003-0364-113X
  • Luis Carlos Sánchez-Martínez Hospital de Especialidades Centro Médico La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, México https://orcid.org/0000-0002-4313-2711
  • Benjamín Acosta-Cazares Hospital de Especialidades Centro Médico La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, México
  • Blanca Sandra Ruíz-Betancourt Coordinación de Vigilancia Epidemiológica, Instituto Mexicano del Seguro Social, Ciudad de México, México https://orcid.org/0000-0001-5135-3189

DOI:

https://doi.org/10.48193/revistamexicanadeurologa.v79i5.380

Keywords:

Prostate cancer, Risk factors, Sexual behavior

Abstract

Prostate cancer is the neoplasia that has the greatest impact on the male population. Its known risk factors are age, race, and genetics, whereas others, such as sexual behavior, have not been established.

Objective: To measure the association of sexual behavior and other factors with prostate cancer in a Mexican population.

Materials and methods: A paired case-control study was conducted, in which the cases were patients with adenocarcinoma of the prostate and the controls were patients with no PCa, paired by ± 3 years of age. The study variable data were obtained through a confidential medical interview and hospital case records.

Results: Beginning sexual relations after 18 years of age had an OR of 2.82 (95% CI 1.27-6.25), being single had an OR of 16.4 (95% CI 5.42-49.65), sexual intercourse with sex workers had an OR of  8.75 (95% CI 3.66-20.9), and a history of a sexually transmitted disease had an OR of 2.49 (95% CI 1.24-4.99).

Conclusions: A late beginning of sexual relations, being single, sexual intercourse with sex workers, and a history of a sexually transmitted disease were the male sexual behaviors associated with the risk for presenting with prostate cancer. We found no association with the number of sexual partners or the frequency of sexual intercourse.

References

Lee D, Lee C, Kwon T, You D, Jeong IG, Hong JH, et al. Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia. Korean J Urol. 2015 Aug;56(8):565–71. doi: https://dx.doi.org/10.4111%2Fkju.2015.56.8.565

Amano K, Maeda I, Shimoyama S, Shinjo T, Shirayama H, Yamada T, et al. The Accuracy of Physicians’ Clinical Predictions of Survival in Patients With Advanced Cancer. J Pain Symptom Manage. 2015 Aug;50(2):139-146.e1. doi: https://doi.org/10.1016/j.jpainsymman.2015.03.004

Ramírez-Backhaus M, González-Tampán J, Ortiz-Rodríguez IM, Gómez-Ferrer Á, Rubio-Briones J, Collado-Serra A, et al. Urinary tract symptoms and erectile function in patients at risk of prostate cancer. Actas Urol Esp. 2015 Aug;39(6):360–6. doi: https://doi.org/10.1016/j.acuro.2014.10.005

Touijer KA, Mazzola CR, Sjoberg DD, Scardino PT, Eastham JA. Long-term Outcomes of Patients with Lymph Node Metastasis Treated with Radical Prostatectomy Without Adjuvant Androgen-deprivation Therapy. European Urology. 2014 Jan 1;65(1):20–5. doi: https://doi.org/10.1016/j.eururo.2013.03.053

Center MM, Jemal A, Lortet-Tieulent J, Ward E, Ferlay J, Brawley O, et al. International variation in prostate cancer incidence and mortality rates. Eur Urol. 2012 Jun;61(6):1079–92. doi: https://doi.org/10.1016/j.eururo.2012.02.054

Gómez-Dantés H, Lamadrid-Figueroa H, Cahuana-Hurtado L, Silverman-Retana O, Montero P, González-Robledo MC, et al. The burden of cancer in Mexico, 1990-2013. Salud Publica Mex. 2016 Apr;58(2):118–31. doi: https://doi.org/10.21149/spm.v58i2.7780

Lynch HT, Kosoko-Lasaki O, Leslie SW, Rendell M, Shaw T, Snyder C, et al. Screening for familial and hereditary prostate cancer. Int J Cancer. 2016 Jun 1;138(11):2579–91. doi: https://doi.org/10.1002/ijc.29949

Khani F, Mosquera JM, Park K, Blattner M, O’Reilly C, MacDonald TY, et al. Evidence for molecular differences in prostate cancer between African American and Caucasian men. Clin Cancer Res. 2014 Sep 15;20(18):4925–34. doi: https://doi.org/10.1158/1078-0432.CCR-13-2265

Farrell J, Petrovics G, McLeod DG, Srivastava S. Genetic and molecular differences in prostate carcinogenesis between African American and Caucasian American men. Int J Mol Sci. 2013 Jul 25;14(8):15510–31. doi: https://doi.org/10.3390/ijms140815510

Sawada N. Risk and preventive factors for prostate cancer in Japan: The Japan Public Health Center-based prospective (JPHC) study. J Epidemiol. 2016 Nov 15;27(1):2–7. doi: https://dx.doi.org/10.1016%2Fj.je.2016.09.001

Curtis A, Ondracek RP, Murekeyisoni C, Kauffman E, Mohler J, Marshall J. Tobacco use and outcome in radical prostatectomy patients. Cancer Med. 2017 Apr;6(4):857–64. doi: https://doi.org/10.1002/cam4.1041

Vainshelboim B, Müller J, Lima RM, Nead KT, Chester C, Chan K, et al. Cardiorespiratory fitness and cancer incidence in men. Ann Epidemiol. 2017;27(7):442–7. doi: https://doi.org/10.1016/j.annepidem.2017.06.003

Ganesh B, Saoba SL, Sarade MN, Pinjari SV. Risk factors for prostate cancer: An hospital-based case-control study from Mumbai, India. Indian J Urol. 2011 Jul;27(3):345–50. doi: https://doi.org/10.4103/0970-1591.85438

Pacheco SOS, Pacheco FJ, Zapata GMJ, Garcia JME, Previale CA, Cura HE, et al. Food Habits, Lifestyle Factors, and Risk of Prostate Cancer in Central Argentina: A Case Control Study Involving Self-Motivated Health Behavior Modifications after Diagnosis. Nutrients. 2016 Jul 9;8(7). doi: https://doi.org/10.3390/nu8070419

Nair-Shalliker V, Yap S, Nunez C, Egger S, Rodger J, Patel MI, et al. Adult body size, sexual history and adolescent sexual development, may predict risk of developing prostate cancer: Results from the New South Wales Lifestyle and Evaluation of Risk Study (CLEAR). Int J Cancer. 2017 Feb 1;140(3):565–74. doi: https://doi.org/10.1002/ijc.30471

Wang Y-C, Chung C-H, Chen J-H, Chiang M-H, Ti-Yin null, Tsao C-H, et al. Gonorrhea infection increases the risk of prostate cancer in Asian population: a nationwide population-based cohort study. Eur J Clin Microbiol Infect Dis. 2017 May;36(5):813–21. doi: https://doi.org/10.1007/s10096-016-2866-7

Hennis AJM, Wu S-Y, Nemesure B, Leske MC. Urologic characteristics and sexual behaviors associated with prostate cancer in an african-Caribbean population in barbados, west indies. Prostate Cancer. 2013;2013:682750. doi: https://doi.org/10.1155/2013/682750

Plata Bello A, Concepcion Masip T. Prostate cancer epidemiology. Arch Esp Urol. 2014 Jun;67(5):373–82.

Kim SH, Kim S, Joung JY, Kwon W-A, Seo HK, Chung J, et al. Lifestyle Risk Prediction Model for Prostate Cancer in a Korean Population. Cancer Res Treat. 2018 Oct;50(4):1194–202. doi: https://dx.doi.org/10.4143%2Fcrt.2017.484

Vázquez-Salas RA, Torres-Sánchez L, López-Carrillo L, Romero-Martínez M, Manzanilla-García HA, Cruz-Ortíz CH, et al. History of gonorrhea and prostate cancer in a population-based case-control study in Mexico. Cancer Epidemiol. 2016 Feb;40:95–101. doi: https://doi.org/10.1016/j.canep.2015.12.001

Bashir MN, Ahmad MR, Malik A. Risk factors of prostate cancer: a case-control study in Faisalabad, Pakistan. Asian Pac J Cancer Prev. 2014;15(23):10237–40. doi: https://doi.org/10.7314/apjcp.2014.15.23.10237

Ballon-Landa E, Parsons JK. Nutrition, physical activity, and lifestyle factors in prostate cancer prevention. Curr Opin Urol. 2018 Jan;28(1):55–61. doi: https://doi.org/10.1097/MOU.0000000000000460

Sato C, Kaneko S, Sato A, Virgona N, Namiki K, Yano T. Combination Effect of δ-Tocotrienol and γ-Tocopherol on Prostate Cancer Cell Growth. J Nutr Sci Vitaminol. 2017;63(5):349–54. doi: https://doi.org/10.3177/jnsv.63.349

Stott-Miller M, Wright JL, Stanford JL. MSMB gene variant alters the association between prostate cancer and number of sexual partners. Prostate. 2013 Dec;73(16):1803–9. doi: https://doi.org/10.1002/pros.22719

Taylor ML, Mainous AG, Wells BJ. Prostate cancer and sexually transmitted diseases: a meta-analysis. Fam Med. 2005 Aug;37(7):506–12.

Published

2019-11-15

Issue

Section

Original articles