Bilateral synchronous testicular cancer with histopathological discordance: literature review

Authors

DOI:

https://doi.org/10.48193/wna8m219

Keywords:

Bilateral Testicular Tumor, Histopathological Discordance, Synchronous tumor

Abstract

Introduction: Bilateral testicular tumors are very rare, representing between 1 % and 5 % of all testicular germ cell tumors (TGCT). The vast majority of primary bilateral TGCTs are metachronous, while synchronous tumors account for approximately 0.5 % to 1 % of all cases. Synchronous tumors mostly share the same histological pattern, predominantly seminoma, and synchronous bilateral TGCTs (SBTGCT) with discordant subtypes are extremely rare.

Relevance & discussion: The atypical presentation of synchronous bilateral testicular carcinoma with metastatic histopathological discordance poses a therapeutic challenge. Historically, the pathogenesis behind the development of synchronous bilateral TGCTs has been a controversial and still undetermined topic. Apparently are result from separate oncological mechanisms and occur as the development of two independent primary tumors. Clinical case: A 19-year-old male presented with swelling in the left side of the neck. The biopsy reported an embryonal carcinoma, confirmed by ultrasound and tumor markers, revealing bilateral testicular tumors. A left radical orchiectomy was performed, resulting in a mixed germ cell tumor, followed by a right radical orchiectomy after chemotherapy, which yielded a teratoma.

Conclusion: It is known that synchronous primary bilateral testicular germ cell tumors (TGCTs) typically present with similar histology; however, we discuss discordant histology presentations.

Author Biography

  • Victor Enrique Corona-Montes, Secretaría de Salud, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México.

    Dr. Víctor Enrique Corona Montes is a passionate surgeon specialized in oncological urology. Expert in diagnosis and treatments with minimally invasive surgery for prostate cancer, kidney cancer, bladder cancer and other urological conditions.

    He obtained the title of Doctor (UMSNH) and immediately completed a specialization in Urological Surgery (UNAM). In 2011, he travels to France to learn from the best Master in the field of minimally invasive urological surgery, Professor Richard Gaston, in Bordeaux, France. Dr. Corona performed around 800 robotic surgeries with his Master Gastón and returned to Mexico to open the first Robotic Surgery program in Mexico City in 2013 with a radical robot-assisted prostatectomy 8 years ago in Mexico.

    In 2015, he completed a second clinical fellowship in Oncological Urology (High Specialty) at the Fundació Puigvert in Barcelona, ​​Spain, this time under the tutelage of Professor Joan Palou Redorta, current director of the Fundació Puigvert.

    Currently, Dr. Corona is Deputy Director of Surgical Specialties at the General Hospital of Mexico, Founder and Head of the High Specialty Program in Laparoscopic and Robotic Surgery in Urology for UNAM (National Autonomous University of Mexico) and for Mexico, as well as member of the Academic Committee of Urology, of the same University.

    Ex-Coordinator of the Laparoscopy and Endourology Section of the Mexican Society of Urology (S.M.U.) between 2013-2016 and Ex- Coordinator of Urological Tumors of the Mexican Society of Oncology for the 2017-2019 cycle (SMeO)

    Author of numerous national and international scientific publications (articles, book chapters), as well as lecturer, trainer (IRCAD France and Brazil), speaker at the international level. He is constantly updated after taking Oncology courses at the Universities of Tampa and Chicago, as well as an active participant in the Oncology Urology Symposia at Mont Sinai Hospital in New York.

    In addition to sharing experiences with their students and their classmates. He has 3 master's degrees, one in Administration of Health Institutions, (U. Anáhuac), one in History of Medicine from the Descartes University of Paris and a Master's in Education from the Tecnológica University. He also has a specialty in Corporate Health and Wellness (U. Anáhuac) and a Doctorate in Senior Management (CEPEM).

    He is fluent in 5 languages ​​and is currently studying one more.

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Published

2025-06-02

Issue

Vol. 85 No. 2 (2024): March-April

Section

Review articles

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