Human Papillomavirus Infection and prostate cancer in Mexico
DOI:
https://doi.org/10.48193/nbptx523Keywords:
HPV, Prostate Cancer, MexicoAbstract
The association between Prostate Cancer (PCa) and Human Papillomavirus (HPV) infection has been well documented in the world, but little in Mexico. This review describes aspects that link HPV infection with PCa and analyzes the reports carried out in Mexico. The analysis in most reports demonstrated an association, detecting HPV in 14 % of PCa and 8.5 % of benign prostatic hyperplasia; It is suggested that more studies be carried out to establish a role of the virus in the pathogenesis to implement specific prevention strategies in PCa
References
Tsydenova IA, Ibragimova MK, Tsyganov MM, Litviakov NV. Human papillomavirus and prostate cancer: systematic review and meta-analysis. Scientific Reports. 2023;13(1): 16597.
Basulto-Martínez M, Flores-Tapia JP, Conde-Ferráez L, Esuqeda-Mendoza A, Kantun Moreno N, Gómez-Carballo J, et al. [Molecular detection of human papillomavirus among patients with benign prostatic hyperplasia and prostate cáncer.]. Archivos Espanoles De Urologia. 2022;75(1): 27–33.
Medel-Flores O, Valenzuela-Rodríguez VA, Ocadiz-Delgado R, Castro-Muñoz LJ, Hernández-Leyva S, Lara-Hernández G, et al. Association between HPV infection and prostate cancer in a Mexican population. Genetics and Molecular Biology. 2018;41(4): 781–789. https://doi.org/10.1590/1678-4685-GMB-2017-0331.
Dávila- Rodríguez MI, Ignacio- Morales CV, Aragón Tovar AR, Olache-Jiménez, Castelán-Maldonado E, Lara-Miranda S, et al. Human Papilloma Virus Detection by INNOLiPA HPV in Prostate Tissue from Men of Northeast Mexico. Asian Pacific Journal of Cancer Prevention : APJCP. 2016;17(11): 4863–4865. https://doi.org/10.22034/APJCP.2016.17.11.4863.
Martínez-Fierro ML, Leach RJ, Gómez-Guerra LS, Garza-Guajardo R, Johnson-Pais T, Beuten J, et al. Identification of viral infections in the prostate and evaluation of their association with cancer. BMC Cancer. 2010;10(1): 326. https://doi.org/10.1186/1471-2407-10-326.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a cancer journal for clinicians. 2021;71(3): 209–249. https://doi.org/10.3322/caac.21660.
Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2024;74(3): 229–263. https://doi.org/10.3322/caac.21834.
Ferlay J, Ervik M, Lam F, Laversanne M, Colombet M, Mery L, et al. Global Cancer Observatory: Cancer Today (version 1.1). 2024.
Griffin JE. Androgen resistance--the clinical and molecular spectrum. The New England Journal of Medicine. 1992;326(9): 611–618. https://doi.org/10.1056/NEJM199202273260906.
Koochekpour S. Androgen receptor signaling and mutations in prostate cancer. Asian Journal of Andrology. 2010;12(5): 639–657. https://doi.org/10.1038/aja.2010.89.
Shorning BY, Dass MS, Smalley MJ, Pearson HB. The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling. International Journal of Molecular Sciences. 2020;21(12): 4507. https://doi.org/10.3390/ijms21124507.
Taitt HE. Global Trends and Prostate Cancer: A Review of Incidence, Detection, and Mortality as Influenced by Race, Ethnicity, and Geographic Location. American Journal of Men’s Health. 2018;12(6): 1807–1823. https://doi.org/10.1177/1557988318798279.
Bleyer A, Spreafico F, Barr R. Prostate cancer in young men: An emerging young adult and older adolescent challenge. Cancer. 2020;126(1): 46–57. https://doi.org/10.1002/cncr.32498.
Matshela RF, Maree JE, van Belkum C. Prevention and detection of prostate cancer: a pilot intervention in a resource--poor South African community. Cancer Nursing. 2014;37(3): 189–197. https://doi.org/10.1097/NCC.0b013e31829194d2.
Altwaijry N, Somani S, Parkinson JA, Tate RJ, Keating P, Warzecha M, et al. Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL, and interleukin-12. Drug Delivery. 2018;25(1): 679–689. https://doi.org/10.1080/10717544.2018.1440666.
Catalona WJ, Smith DS, Ratliff TL, Dodds KM, Coplen DE, Yuan JJ, et al. Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. The New England Journal of Medicine. 1991;324(17): 1156–1161. https://doi.org/10.1056/NEJM199104253241702.
Termini D, Den Hartogh DJ, Jaglanian A, Tsiani E. Curcumin against Prostate Cancer: Current Evidence. Biomolecules. 2020;10(11): 1536. https://doi.org/10.3390/biom10111536.
Russo GI, Calogero AE, Condorelli RA, Scalia G, Morgia G, La Vignera S. Human papillomavirus and risk of prostate cancer: a systematic review and meta-analysis. The Aging Male: The Official Journal of the International Society for the Study of the Aging Male. 2020;23(2): 132–138. https://doi.org/10.1080/13685538.2018.1455178.
Moghoofei M, Keshavarz M, Ghorbani S, Babaei F, Nahand JS, Tavakoli A, et al. Association between human papillomavirus infection and prostate cancer: A global systematic review and meta-analysis. Asia-Pacific Journal of Clinical Oncology. 2019;15(5): e59–e67. https://doi.org/10.1111/ajco.13124.
Murray PR, Rosenthal K, Pfaller MA. Microbiología médica.. 9th ed. 2021.
Ochoa-Carrillo FJ. Virus del papiloma humano. Desde su descubrimiento hasta el desarrollo de una vacuna. Parte I/III. Gaceta mexicana de oncología. 2014;13(5): 308–315.
Ahmed MY, Salman NA, Sandhu S, Cakir MO, Seddon AM, Kuehne C, et al. Detection of high-risk Human Papillomavirus in prostate cancer from a UK based population. Scientific Reports. 2023;13(1): 7633. https://doi.org/10.1038/s41598-023-34734-3.
McNicol PJ, Dodd JG. High prevalence of human papillomavirus in prostate tissues. The Journal of Urology. 1991;145(4): 850–853. https://doi.org/10.1016/s0022-5347(17)38476-8.
Opeyemi Bello R, Willis-Powell L, James O, Sharma A, Marsh E, Ellis L, et al. Does Human Papillomavirus Play a Causative Role in Prostate Cancer? A Systematic Review Using Bradford Hill’s Criteria. Cancers. 2023;15(15): 3897. https://doi.org/10.3390/cancers15153897.
Lawson JS, Glenn WK. Evidence for a causal role by human papillomaviruses in prostate cancer - a systematic review. Infectious Agents and Cancer. 2020;15: 41. https://doi.org/10.1186/s13027-020-00305-8.
Glenn WK, Ngan CC, Amos TG, Edwards RJ, Swift J, Lutze-Mann L, et al. High risk human papilloma viruses (HPVs) are present in benign prostate tissues before development of HPV associated prostate cancer. Infectious Agents and Cancer. 2017;12: 46. https://doi.org/10.1186/s13027-017-0157-2.
Weijerman PC, König JJ, Wong ST, Niesters HG, Peehl DM. Lipofection-mediated immortalization of human prostatic epithelial cells of normal and malignant origin using human papillomavirus type 18 DNA. Cancer Research. 1994;54(21): 5579–5583.
Arriaga-Izabal D, Morales-Lazcano F, Canizalez-Román A. Human papillomavirus and prostate cancer in Mexican men: a systematic review and meta-analysis. Cancer causes & control: CCC. 2025; https://doi.org/10.1007/s10552-025-01989-2.
Sharad S, Dobi A, Srivastava S, Srinivasan A, Li H. PMEPA1 Gene Isoforms: A Potential Biomarker and Therapeutic Target in Prostate Cancer. Biomolecules. 2020;10(9): 1221. https://doi.org/10.3390/biom10091221.
Sadri Nahand J, Esghaei M, Hamidreza Monavari S, Moghoofei M, Jalal Kiani S, Mostafaei S, et al. The assessment of a possible link between HPV-mediated inflammation, apoptosis, and angiogenesis in Prostate cancer. International Immunopharmacology. 2020;88: 106913. https://doi.org/10.1016/j.intimp.2020.106913.
Khatami A, Nahand JS, Kiani SJ, Khoshmirsafa M, Moghoofei M, Khanaliha K, et al. Human papilloma virus (HPV) and prostate cancer (PCa): The potential role of HPV gene expression and selected cellular MiRNAs in PCa development. Microbial Pathogenesis. 2022;166: 105503. https://doi.org/10.1016/j.micpath.2022.105503.
Alarcón-Romero LDC, Organista-Nava J, Gómez-Gómez Y, Ortiz-Ortiz J, Hernández-Sotelo D, Del Moral-Hernández O, et al. Prevalence and Distribution of Human Papillomavirus Genotypes (1997-2019) and Their Association With Cervical Cancer and Precursor Lesions in Women From Southern Mexico. Cancer Control: Journal of the Moffitt Cancer Center. 2022;29: 10732748221103331. https://doi.org/10.1177/10732748221103331.
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