Inhibición de puntos de control: el tratamiento actual del carcinoma de células renales


  • Juan Esteban García-Robledo Mayo Clinic, Phoenix, Arizona, United States of America.
  • Herney Andrés García-Perdomo Division of Urology/Uro-oncology, Department of Surgery, School of Medicine, Universidad del Valle, Cali, Colombia.


Palabras clave:

inmunoterapia, , carcinoma de células renales, punto de control inmunitario, supervivencia global


La vigilancia inmunológica es una de las características más importantes del cáncer. En la última década se han desarrollado muchos avances en el tratamiento del cáncer, muchos de ellos relacionados con el uso del sistema inmunológico. El carcinoma de células renales es el tipo de cáncer de riñón más frecuente seguido del carcinoma urotelial. Durante años, el tratamiento del Carcinoma de Células Renales ha sido conflictivo ya que estos tumores no responden bien a la quimioterapia y han demostrado ser susceptibles a inmunoterapias como el interferón y la interleucina 2. El descubrimiento de los puntos de control inmunitarios y su posible papel en el tratamiento del cáncer llevó a la síntesis de nuevos fármacos que pueden dirigirse e inhibir la interacción de ciertas moléculas que son importantes para la homeostasis inmunológica. En esta revisión concisa, resumimos la evidencia relacionada con la inhibición del punto de control inmunitario para el tratamiento del carcinoma de células renales, especialmente para el carcinoma metastásico de células renales.


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