Efectos de la toxina botulínica sobre la porción glandular de la próstata: fundamentos fisiopatológicos, mecanismo de acción y evidencias

  • Alberto Piamo Morales Hospital General “Dr. José Gregorio Hernández”
  • Daisy Ferrer Marrero Universidad de Ciencias Médicas de La Habana
Palabras clave: próstata, cáncer de próstata, toxina botulínica, atrofia

Resumen

La toxina botulínica es una potente neurotoxina que produce la inhibición de las uniones neuromusculares mediante el bloqueo de la liberación de acetilcolina y desensibilización de los nervios sensoriales. En la próstata, sus efectos no solo se limitan a la unión neuromuscular, sino que también se extienden a la unión neuroglandular. Por lo cual la inyección intraprostáticas de toxina botulínica se encuentra entre las nuevas opciones de tratamiento de la hiperplasia prostática benigna. Considerando las potencialidades que esta sustancia posee como una terapia efectiva en afecciones prostáticas, pero considerando que sus mecanismos son poco claros, el objetivo de esta revisión es organizar la evidencia actual y describir los fundamentos fisiopatológicos y mecanismo de acción conocidos hasta ahora, con la finalidad de motivar nuevas investigaciones. Luego de realizar la revisión de la evidencia se pudo concluir que la toxina botulínica puede inducir la involución prostática en ratas, perros y humanos sin causar inflamación local o efectos secundarios sistémicos significativos. Lo cual plantea la posibilidad de su aplicación en lesiones prostáticas benignas o malignas.

Citas

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Publicado
2020-08-11
Sección
Artículos de revisión