Also available in: Español
Rev Mex Urol. 2018 November-December;78(6):419-24 DOI: https://doi.org/10.24245/revmexurol.v78i6.2419
Denisse Stephania Becerra-Loaiza,1 Jorge Guillermo Sánchez-Zazueta,2 Luis Antonio Ochoa-Ramírez,1 Ismael Velarde-Rodríguez,3José Rodríguez-Millán,4 Jesús Salvador Velarde-Félix1,2,5
1 Postgraduate Degree in Biomedic Sciences, Chemical-Biologic Sciences Faculty.
2 Immunogenetic and Evolution Academic Body UAS-CA-265, Biology Faculty.
3 Medicine Faculty, Universidad Autónoma de Sinaloa, México.
4 Department of Internal Medicine.
5 Department of Genomic Medicine.
Hospital General de Culiacán Dr. Bernardo J. Gastélum, Culiacán, Sinaloa.
OBJECTIVE: To evaluate the influence of the polymorphisms of the vitamin D receptor gene (FokI: rs2228570, BsmI: rs1544410, ApaI: rs7975232, and TaqI: rs731236) on the clinical parameters of patients with urinary tract infections.
MATERIALS AND METHODS: A comparative, prospective, and cross-sectional study was conducted at the Hospital General de Culiacán Dr. Bernardo J. Gastélum within the time frame of August 2016 to July 2017. The polymorphisms were detected through the polymerase chain reaction-restriction fragment length method in 119 patients diagnosed with urinary tract infection and in 206 individuals with no urinary tract infection. The data analysis was carried out using the χ2 and odds ratio (OR) with a 95% confidence interval (95%CI). The logistic regression method, adjusted by age and sex, was employed to evaluate the relation between clinical characteristics and genotypes, utilizing the STATA version 13.0 program. Statistical significance was set at a p<0.05.
RESULTS: We found differences in the prevalence of the CA-ApaI genotype between the study groups. The FokI and BsmI polymorphisms and the TGAT and CGCT haplotypes were associated with certain clinical characteristics.
CONCLUSIONS: A possible link between the vitamin D receptor gene and bacterial urinary tract infection in a Mexican population was suggested.
KEYWORDS: Vitamin D receptor; Urinary tract infection; Polymorphisms; Haplotypes.
Jesús Salvador Velarde Félix